News

Key Strategies for Implementing Proteomics-Based Tests Across Disease States Highlighted in Current Opinion in Biotechnology

ISB, Integrated Diagnostics and Sera Prognostics just announced a paper entitled, “The building blocks of successful translation of proteomics to the clinic,” by Leroy Hood and colleagues published online in Current Opinion in Biotechnology.

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Warhol style Plasmodium

The Other Malaria: Finding New Targets for a Vaccine Against Plasmodium vivax

A new report in PLOS Neglected Tropical Diseases describes the results of an international collaboration led by researchers at ISB and Seattle’s Center for Infectious Disease Research (CIDResearch). We used mass spectrometry-based proteomics to identify nearly 2,000 proteins present in Plasmodium vivax parasites, one of the Plasmodium species that cause the disease malaria in humans. The work was done on parasites dissected from mosquito salivary glands, parasites that were in…

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ISB Proteomics: Moritz Lab Hosts TPP Workshop in Delhi

A team from the Moritz Lab at ISB headed to Delhi, India, to host a workshop on the Trans-Proteomic Pipeline (TPP). @ISBUSA Luis Mendoza and Dave Campbell open up the TPP course in Delhi India today to teach proteomics from the Moritz Lab. Welcome students pic.twitter.com/01hkteGfrr — rmoritz (@r_l_moritz) December 9, 2016 Many thanks from the Moritz lab @ISBUSA to the TPP Delhi Course participants and thanks to Brijesh Pandey…

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Promotion: Michael Hoopmann Becomes Senior Research Scientist

Congratulations to Dr. Michael Hoopmann, of the Moritz Lab, who has been promoted to Senior Research Scientist. His research is focused on proteomics technology and methods development, having been trained in both instrumentation and software data analysis, with particular focus on high-resolution mass spectrometry. His current interests are in the development of advanced algorithms for discovery-based proteomics. He is the developer of the Kojak algorithm, a versatile, open-source software application…

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‘A Better Blood Test for Liver Damage’

Chemical & Engineering News highlighted ISB’s recent publication (Identifying Organ-Specific Blood Biomarkers for Acute Liver Injury) in the Journal of Proteome Research. “For many years, clinicians have relied on assays for two enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), to detect liver injury. These biomarkers have limitations, says Leroy Hood of the Institute for Systems Biology, such as a short half-life and a tendency to underreport damage in certain…

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Wilke Cohen Lyme Disease Project Receives $3M from the Steven & Alexandra Cohen Foundation

PRESS RELEASE Total Funding Has Reached $6.1 Million ISB Researchers Have Discovered Potential Biomarkers and Successfully Reproduced the Borrelia Bacteria in the Lab SEATTLE – June 1, 2016 – Institute for Systems Biology (ISB) has received a transformational, multi-year pledge from the Steven & Alexandra Cohen Foundation to support the Wilke Cohen Lyme Disease Project. In addition to an initial $3.1 million in funding from Jeff and Liesl Wilke, Jeff…

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Dr. Kristian Swearingen, ISB research scientist.

Dissecting Mosquitoes is Hard!

Photo by Hsiao-Ching Chou Dr. Kristian Swearingen is a research scientist in the Moritz Lab at ISB. He and his collaborators just published a paper in PLOS Pathogens that describes potential new targets for malaria vaccines. Read his article about the research. Asked about the challenge of having to dissect thousands of mosquitoes, he commented: When we started this project, my collaborators collected all the parasites and I focused on…

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ISB Q&A: Dr. Robert Moritz on Ötzi the Iceman

Ötzi the Iceman: In a study published in the Jan. 8, 2016, issue of the journal Science, researchers from the Moritz group at ISB collaborated with a worldwide consortia headed by Prof. Albert Zink and Dr. Frank Maixner, of the Institute for Mummies and the Iceman at the European Academy of Bozen/Bolzano (EURAC) in Italy; Prof. Thomas Rattei, of the University of Vienna; and Dr. Rudi Grimm, of University of…

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The 5300-year-old Helicobacter pylori genome of the Iceman

ISB’s Moritz Group, which specializes in proteomics, collaborated on research related to study pathogens from the stomach content and microbiome of Ötzi, a glacier mummy from the European Copper Age. The results were published in Science. Read the article here. Institute for Systems Biology collaborates with researchers worldwide to study pathogens in the stomach content and microbiome of the 5300 year old European Copper Age glacier mummy “Ötzi” and discovers…

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Dr. Robert Moritz Promoted to Professor

A message from… By Dr. Lee Hood President, Institute for Systems Biology As most of you know, Rob Moritz has recently been promoted to full professor at ISB—a promotion long overdue. As long as I have known Rob, he has always done things without fuss, but this time we will toast him for his achievement. He also wants to credit the efforts of his group for their significant contributions that…

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ISB releases open-source software to analyze digital fingerprint of protein data

3 Bullets SWATH mass spectrometry, an emerging protein analysis technique being pioneered by ISB researchers, provides a digital fingerprint of all accessible proteins in a sample. The data generated by the SWATH technique are highly complex and require sophisticated computational tools in order to extract identities from a sea of data. ISB researchers have released a free, open source program that allows users to confidently identify and quantify proteins analyzed…

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ISB’s Robert Moritz Lab Receives NIGMS Grant for Trans Proteomic Pipeline

The National Institute Of General Medical Sciences of the NIH has awarded Principal Investigator(s): Eric Deutsch, PhD, and Robert L. Moritz, PhD, a continuing R01 grant GM087221 for the ongoing development of the Trans-Proteomic Pipeline. The award titled “Development of Trans Proteomic Pipeline, an Analysis Suite for Mass Spectrometry” will continue the work of the ISB flagship proteomics analysis suite of open-source programs that has been downloaded thousands of times…

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ISB’s Robert Moritz Lab Receives NIGMS Grant for Trans Proteomic Pipeline

The National Institute Of General Medical Sciences of the NIH has awarded Principal Investigator(s): Eric Deutsch, PhD, and Robert L. Moritz, PhD, a continuing R01 grant GM087221 for the ongoing development of the Trans-Proteomic Pipeline. The award titled “Development of Trans Proteomic Pipeline, an Analysis Suite for Mass Spectrometry” will continue the work of the ISB flagship proteomics analysis suite of open-source programs that has been downloaded thousands of times…

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