Infectious Disease

Related Projects

  • The Bug Stops Here: Arresting Malaria Parasites in the Liver Gives Immunity

    ISB researchers collaborated with Seattle BioMed researchers to identify molecular building blocks required by malaria parasites to build cell membranes. Deleting key genes necessary for building cell membranes created a parasite that does not make the host sick and can’t be passed on through the blood. Treating mice with modified parasites gave them complete immunity against malaria. By Dr. Kristian Swearingen In a study published online in the journal Molecular…

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  • New Protein Modification Critical to Growth of Tuberculosis Pathogen Found

    Institute for Systems Biology and Seattle BioMed researchers collaborated and discovered a new protein post-translational modification in the human pathogen Mycobacterium tuberculosis. Post-translational modifications are essential mechanisms used by cells to diversify protein functions and ISB scientists identified the rare phosphorylated tyrosine post translational modification on Mycobacterium tuberculosis proteins using mass spectrometry. Inhibiting phosphotyrosine modified amino acids in Mycobacterium tuberculosis severely limits the growth of this widespread deadly pathogen. By…

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  • A New Approach to Identifying How the Deadly Dengue Virus Multiplies

    3 Bullets Dengue virus is the most prevalent mosquito-borne virus worldwide, infecting an estimated 400 million people per year and causing about 25,000 deaths. It’s necessary to understand the molecular mechanisms of dengue replication in order to develop an effective treatment. Researchers at ISB and Seattle BioMed developed a novel approach for identifying host proteins that associate with dengue replication machinery. By Thurston Herricks Dengue virus (DENV) infects approximately 400…

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